Losing weight on GLP-1 medications like Ozempic or Mounjaro is only part of the equation. Without the right workout plan, you risk losing muscle along with fat, which impacts your metabolism and results long term. This guide breaks down the most effective approach: strength training with progressive overload 3 to 5 days per week to protect muscle, support fat loss, and build a strong, defined body while you’re on a GLP-1.